In addition, the airlines' operations have been considerably disrupted by 22 air traffic control strikes in Europe so far this year.
Ferry services have been considerably disrupted and falling trees have caused some problems on roads and railways.
Household heads perceived that climate change considerably disrupted raining seasons and caused repeating occurrences of droughts, temperature change, prevalence of diseases, drying of water sources and lack of human and livestock feed.
Evidence of illuviation in the colluvial soils is provided by the increase in the clay content and the fine to total clay ratio in the subsoil and by the well-developed, but considerably disrupted, clay coatings observed in thin sections.
As Ford expected, Turkish relations were considerably disrupted until 1978.
Replacement of the residues Tyr, Asn, His, Tyr, and Tyr with alanine residues considerably disrupted the ability of Keap1 to bind to Nrf2.
Finally, EPLIN also appears to be important for attachment to F-actin in endothelial cells; when EPLIN expression is downregulated, the organisation of F-actin is considerably disrupted, leading to multiple holes in the actin cytoskeleton [ 38].
Collectively, evidence is mounting that TET2 inactivation in cancer may alter more than just DNA methylation; in fact, transformation may result considerably from disrupted interactions with other epigenetic regulators and development-associated transcription factors.
In common with our earlier observations, both F-actin and myosin appeared considerably more disrupted in Celsr1 Crsh than in Vangl2 Lp.
This pressure dependence were due to the difference in cell membrane and cell wall properties especially for yeast cells, which are considerably harder to disrupt due to its overall very thick and resistant cell wall structure [ 35, 36].
