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The survival advantage of sipuleucel-T has considerably challenged the dogma that prostate cancer is not an immunotherapy-sensitive tumor.
24 Hospital eye services are considerably challenged by the influx of new glaucoma referrals, while continuing to monitor existing stable patients.
The failure of almost all anti-inflammatory agents to improve survival and the finding that the initial hyper-inflammatory response in sepsis is quickly followed by an immunocompromised state have considerably challenged this concept.
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It is considerably challenging to alter the design of existing large and tall buildings to make them rely on natural energy due to many reasons.
These special difficulties and performance objectives make the scheduling problem in BWA networks considerably challenging.
Compensation of sparse ISI channels is considerably challenging since these channels can often have very long delay spreads, and optimal approaches like BCJR and Viterbi are therefore infeasible.
The diagnosis of chronic radiation enteritis (CRE) is considerably challenging both for clinicians and radiologists.
The present study considerably challenges current taxonomic hypotheses in these two species complexes, and paves the way for future revisions.
However, the demand for guidance, even in the face of weak associations and incomplete data, can be considerably challenging to regulators and expert panels dealing in the public health arena.
Substantial sweat losses and extensive related body water and electrolyte deficits are not uncommon, 1 5 as is a level of thermal strain that considerably challenges a player's physiology, perception of effort and on-court well-being and performance.
Competitive tennis in the heat can prompt substantial sweat losses and extensive consequent body water and electrolyte deficits, as well as a level of thermal strain that considerably challenges a player's physiology, perception of effort, and on-court well-being and performance.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com