Sentence examples for considerable tissue damage from inspiring English sources

The histological effects of cisplatinum and vincristine administration were not as affected as tumor kinetics by telomere shortening, probably due to the considerable tissue damage exerted by the cytotoxic drugs per se.

Cytotoxic chemotherapy has focused on DNA damage and disruption of the cell cycle in rapidly dividing cells, with nonselective cell death and considerable toxicity from healthy tissue damage.

However, there was considerable histologic evidence of tissue damage in the TNF-α treated hearts, suggesting the relative insensitivity of CPK in detecting lesser myocardial injuries.

Contrary to this, biopsy studies of the colitis-Lf1 treatment group demonstrated considerable improvement in the tissue damage as can be reflected from the intact epithelium with mild, acute, and chronic inflammatory infiltration of lymphocytes.

However, they provoke considerable acute and delayed normal tissue damage, in particular of the heart.

Deep ulcer is of considerable clinical concern as the tissue damage is already very severe by the time the ulceration becomes visible and detectable at the cutaneous layer.

These studies not only demonstrate that TREM-1 plays a critical role in host immune response, but also suggest that therapeutic targeting of TREM-1 after surgical hit or tissue damage holds considerable promise by dampening excessive inflammation while maintaining effective microbial control.

Tissue damage resulting from acute or chronic exercise ranges from considerable fiber disruption to subcellular damage [ 2, 3].

Skeletal tissue damage caused by trauma, injury, or disease can often result in considerable morbidity and the need for new, more reliable strategies for skeletal regeneration.

There is also considerable evidence that temporary decrease or interruption in oxygen supply to the embryo and ROS generation during reperfusion result in tissue damage in embryonic tissues.

Severe tissue damage can occur.