Exact(2)
In bread wheat (Triticum aestivum L ., despite the availability of considerable sequence information in Expressed Sequence Tag (EST) database, it is difficult to design genome-specific PCR primers because of the presence of three very closely related homoeologs.
Additionally, sequencing of genomes for many other Bacteroidetes/Chlorobi species is at different stages of completion (see Table 1), but considerable sequence information for these genomes is available in the NCBI database.
Similar(6)
How can we formulate a peptide or protein sequence with a vector yet still keep considerable sequence order information?
One of the most important but also most difficult problems in computational biology is how to formulate a biological sequence with a discrete model or a vector, yet still keep considerable sequence order information.
Such investigations have already generated considerable DNA sequence information from extinct mammals, including complete mtDNA genomes from ancient woolly mammoth, thylacine, rhinoceroses and hominid samples, giving new insight into their evolutionary history [21], [22], [23], [24], [25], [26], [27], [28], [29].
Actually, one of the most important but also most difficult problems in computational biology is how to effectively formulate a biological sequence with a discrete model or a vector, yet still keep considerable sequence-order information.
This characteristic will allow us to implement approaches that would save a considerable amount of time for phylogenetic reconstructions using the entire sequence information available in genome-scale data.
In view of the considerable ambiguity in interpreting the significance of gene divergence even when sequence information is available, the focus on gene divergence in M-CGH studies must be re-assessed.
Related(1)
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