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However, even considerable sequence divergence between an mRNA and the dsRNA does not rule-out unintentional gene silencing since, once ingested, the dsRNA is cleaved into numerous very short (19 23 nucleotides) small interfering RNAs (siRNA).
These different TAAs achieve their tightly interwoven trimeric structures despite considerable sequence divergence and different domain architecture.
The considerable sequence divergence between the three novel putative Henipaviruses encountered in one huge colony might indicate substantial genetic variability of related viruses in bats.
Both the overall three-dimensional structure and most details of ligand recognition are highly conserved in the PDZ family despite considerable sequence divergence [28].
In general, TAA sequence motifs are highly modular in nature and often rearranged in different TAAs, yet the structures of sequence motifs such as the Trp-ring motif remain highly similar despite considerable sequence divergence [9], [11].
The considerable sequence divergence of the viruses described herein from pathogenic viruses (Table 2) gives no indication that these penguin viruses pose an imminent threat to the health of humans or live stock.
Similar(32)
However, there has been considerable HA sequence divergence in the recent avian-adapted H2 strains from the pandemic H2N2 strain.
The unusually large number of ligand isoforms that mediate mammalian canonical Wnt signaling display considerable primary sequence divergence.
Heterogeneity in substitution rates among sites within a nucleotide sequence can have considerable impact on sequence divergence [ 56, 119- 121].
Despite a considerable amino-acid sequence divergence, all UDGs share a common alpha beta fold structured catalytic domain (Aravind and Koonin 2000).
Furthermore, the structure of the nucleosome containing the H2A.Z variant is very similar to its canonical counterpart despite considerable amino acid sequence divergence.
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