Furthermore, therapies produce a considerable selection pressure in epigenetic marks that can contribute to therapy resistance.
This might produce considerable selection bias in that help-seeking youth are more likely to be sampled than those who might be avoidant.
Although the decision to perform the echo investigation was taken on a clinical basis in the sickest patients, and therefore contains a considerable selection bias both in terms of patient selection and timing, some remarkable issues were put forward.
The widespread use of such programmes has substantially reduced clinical disease, especially that associated with large strongyle species; however, high treatment frequency has led to considerable selection pressure for anthelmintic resistance, particularly in cyathostomin species.
Consistent with this idea, both codon-based methods used here also show considerable differential selection in the V2 region near the 3' end of the S-RNases, supporting previous analyses of both Lycium [ 16, 23] and Solanum chilense [ 12] S-RNases which also found evidence of selection in this region.
Thus, our study indicates the presence of a considerable positive selection pressure in diversification of the Prochlorococcus core genome, which in turn, suggests an appreciable role of random genetic drift in vertical niche partitioning of the strains.
Despite the difficulties of studying negative selection in vivo, considerable progress has been made towards the understanding of the signaling cascades that are essential for apoptosis of DP thymocytes triggered by strong TCR signals [9].
While considerable evidence suggests that sexual selection in guppies is driven by the multivariate mating preferences of females, male-male competition, male mating tactics, and male mate choice may also be under selection [ 37, 38, 87, 88].
We found considerable variation in selection of trial outcomes; indeed, only 71% reported weaning duration.
Feature selection in incomplete decision table has gained considerable attention in recently.
