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The latter has been proven to be a considerable risk factor for orthodontic root resorption [29].
Importantly, PSC is a considerable risk factor for the development of cholangiocarcinoma (CCA) that results from a malignant transformation of bile duct epithelial cells.
Mental health problems are common in young people with 75% of disorders beginning in adolescence and adolescent onset posing a considerable risk factor for long term psychological problems [ 1].
Although malnutrition has been associated with increased hospitalization, increased susceptibility to infection, reduced QOL, and increased mortality [ 49- 51], nutritional status evaluation may not be afforded sufficient attention in the field of chemotherapy-induced toxicity in patients with NSCLC, who themselves represent a considerable risk factor for complications and co-morbidities.
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In pathogenesis of necrotizing enterocolitis (NEC), both oxidative stress and inflammation are considerable risk factors.
In addition to familial disposition, somatic mutations in key genes pose as considerable risk factors for melanoma.
3, 4 Esophagectomy is a high-risk procedure with serious postoperative complications and a reported mortality rate ranging from 2 to 6%. 1, 3, 5 Moreover, esophageal cancer patients often have considerable risk factors for major surgery, including obesity and pulmonary and cardiovascular diseases.
Male gender, early-onset PD, current or pre-PD personality traits characterized by high impulsivity and novelty-seeking personality traits, family or personal history of ICD symptoms or substance abuse (including current smoking) may all be regarded as considerable risk factors (Weintraub et al. 2010).
Early in life, the expression of extreme BI, characterized by excessively inhibited responses to strangers or novel situations is a considerable risk-factor for the development of anxiety and depression [1] [3].
These were patients with considerable preoperative risk factors; 71 patients (25.2%) died within 1 year (Table 2).
Moreover, amputation rates were significantly (p < 0.0001) lower in the becaplermin (4.9%) than in the control group (6.4%), despite the fact that patients receiving becaplermin had considerable adverse risk factors for healing (increased wound duration and size, increased wound grade at initial visit) (Margolis et al 2005b).
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