Lindberg et al. [ 22] also reported considerable variation in residue levels when sampling was done at various times of the day at the same place.
Nevertheless, the superposition also reveals considerable differences in residue composition and side chain orientation between the binding sites of both proteins (e.g., W53 and the tip of loop C; Fig. 2B D).
Experimental data had suggested that residues outside of the MHC class II binding groove contribute to binding [31], [32] and prediction methods have been developed incorporating such residues with considerable success [30] Our analysis of residue flexibility with the MD simulation data supports this notion.
Disulfide bond formation is speculated to exert considerable effects on residues within the kinase domain, most notably within the active-site cleft.
Considerable weak discernible residues associated with the use of bio-colorants are: reproducibility, cost efficiency, inadequate degree of fixation, and low color fastness properties [59, 93, 94].
Data from publications show [77, 78] a considerable amount of residues from spraying can be expected in genetically engineered soybeans that are resistant to glyphosate formulations.
In hMSC batch 1, moderate hypermethylation by SYT/SSX1 limited to one allele at CpGs 1 23 accompanied by considerable hypomethylation at residues 23 26 on both alleles was also observed.
It is possible, but the alternative explanation, that the linkage is not formed at all in the context of the full-length protein, is more plausible given the considerable number of residues lying in between the motor domain and the C-terminus.
Considerable amounts of unextracted residue (about 30 36%) remained after 48 h of continuous THF extraction of these SIPN blends.
Taken together, these results indicate that changes in the H-bond network, charge transfer and/or size of the target residue have considerable effects on substrate binding and, consequently, the catalytic activity of the mutant proteins.
