Thus, the considerable change in replication elongation rate did not lead to a significant change in the regulation of initiation, but did (in one case) lead to changes in the control of cell division.
Nonetheless, all potentially pose a considerable impediment to DNA replication, as they can block the progression of replicative polymerases (Woodford et al., 1994).
AT-rich regions are known to disfavor nucleosomes [30], therefore a considerable nucleosome depletion at replication origins (∼−0.5 sd units below the genomic average) is in accordance with earlier small-scale experiments [31].
Although HIV-1 does not appear to mount a direct defense against the cellular RNAi machinery, there is considerable evidence that viral replication can be modulated by RNAi and knockdown of Dicer has been shown to up-regulate the production of infectious HIV-1 in primary cells, Jurkat cells, and 293T cells [5], [17], [18].
Raccoon dogs produced high antibody titers against AMDV, supported a considerable level of viral replication, showed some lesions in their kidneys that were similar to those observed in early stages of AMDV infection in the mink, and carried infectious viruses four weeks pi.
Heritability was estimated as twice the slope of the regression in the initial cohort, where only one parent was available, and as the slope of the regression in the replication cohort: with considerable error it ranges between ∼25% (leptin) and ∼63% (TNFα).
There was considerable discussion about the proposed replication.
Because of the considerable absolute number of less replication-competent K65R-harboring viruses in the patient, we assume that this variant has been transmitted.
All the compounds interfered with the replication of picornaviruses, although considerable differences were observed in the sensitivity of viruses to each compound.
In addition the data show that these ORC1/CDC6 binding sites act as replication origins, albeit with considerable redundancy, and that the coordination of transcription and replication is not simply positional.
