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Similarly, in an international RCT on subcutaneous sumatriptan, 6 mg which was done at the same time, it was observed that the migraine recurred in 38% of patients within 24 h after subcutaneous sumatriptan 6 mg [14] Thus even with the most effective way of administering a triptan a considerable recurrence rate was found [15, 16].
Given the considerable recurrence rates, these results suggest adjuvant hormonal treatment to be beneficial in early- and advanced-stage ESS.
However, apart from the minimal trauma resulting from the injection technique, considerable recurrence rates and the need for multiple injections have been reported [ 31, 53].
Several investigators have reported that pathologically confirmed invasive factors was not a rare occurrence and tumors showed a considerable recurrence rate, even when a patient's tumor was classified as clinical stage IA NSCLC [ 1, 19].
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Chronic subdural haematoma (CSDH) is a common entity in neurosurgery with a considerable postoperative recurrence rate.
Patients with stage II melanoma have a considerable risk for recurrence.
All of these methods share a considerable percentage of recurrence.
Despite this intensive, burdensome treatment, patients still have to face a considerable risk of recurrence [ 7].
However, as our data demonstrate, a considerable rate of recurrence can be expected during first, second and even third-line therapy.
Our results suggest satisfactory overall long-term outcome, but short-and mid-term observation showed a considerable rate of recurrence for all strategies applied.
Patients with the same pathological and clinical stage of NSCLC display considerable variability in recurrence and survival (Buccheri and Ferrigno, 1994).
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