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Such close interplay has provided considerable rationale for further clinical trials employing STIs in combination with various antihormonal strategies [ 3].
There is a considerable rationale for promoting multimodal exercise interventions to improve physical capacity, vitality, and physical and mental wellbeing, and to relieve fatigue during chemotherapy; thereby supporting cancer patients' daily living activities.
While additional mechanisms relevant to lupus pathogenesis may also come into play, the effect on TLR signaling provides considerable rationale for use of hydroxy-chloroquine to control disease activity and perhaps inhibit the amplification of immune system activation mediated by type I IFN.
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Thus, there is considerable theoretical rationale for level of goal/action identification influencing self-regulation in clinical contexts, with a concrete level-of-identification implicated in poorer resistance to temptation.
A number of respondents noted that senior administrators could become enablers if they were convinced of the rationale for education, and that they would present a considerable barrier if they were not convinced.
These activities clearly suggest that a considerable effort was made to engage with relevant stakeholders and promote a coherent rationale for service redesign.
The rationale for using a conservative estimation of NTHi pneumonia incidence was informed by the considerable variation amongst estimates reported in the literature [ 30- 34].
Together, these observations provide a strong rationale for WAS gene therapy since low level correction can be expected to provide considerable clinical benefit to the patient (Moratto et al., 2011).
This review summarizes the considerable work that has been performed in the development of the DNT study and provides the rationale for the regulatory acceptance of TG 426 as a new OECD test guideline.
Adding to the rationale for public health action is the recognition that the economic effect of cysticercosis is considerable.
Moreover, the marked heterogeneity of ventilator protocols among these three studies (with resulting considerable differences in plateau pressures between one study [54] and the others [2, 53]) casts some doubt on the physiological rationale for this meta-analysis.
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