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Because of the considerable published data linking metal-binding to the aggregation of Aβ, metal-chelation drugs have been proposed as a potential therapy for AD [40], [41].
We note that considerable published data from other labs supports the idea that Cdc42 itself can transit through the cytoplasm without GDI.
There is considerable published data regarding the efficacy of plant extracts, but information on the toxicity of these natural resources is not sufficient [ 1].
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There is a considerable amount of published data for copper(ii) cyclam complexes going back over more than 30 years.
Maximum efficiency of the unit was found to be 79%, marginally higher than that of the parent pump, while the off-design efficiency offered considerable improvement over previously published data of traditional PAT systems.
There was however considerable overlap with previously published data sets that identified proteins predominantly from phloem exudates, but also from micro-dissected phloem tissues and S-cells.
Moreover, there is considerable difficulty in interpreting the published data regarding prehospital intubation, since the relevant studies frequently have very dissimilar populations that also receive dissimilar care.
Rietveld refinement on the published data reveals considerable preferred orientation [March Dollase parameter r = 0.86 in the direction, which is the normal to the plane containing the N H⋯O=S hydrogen bonds].
However, Rietveld refinement against the published data reveals considerable preferred orientation [March Dollase parameter r = 0.82 in the (100) direction] and when this preferred orientation is included in the real-space crystal-structure solution, a different structure with a lower χ (3.9 versus 4.3) and more reasonable short contacts is found in three of 50 simulated annealing runs.
However, in-house electrophysiology studies designed to confirm the selectivity of TPA023 and TP003 for human GABAA receptors did not corroborate published data, with TP003 displaying considerable GABAA-α5 receptor efficacy.
A structurally diverse array of xenobiotics was chosen (Table 1) to represent a broad spectrum of chemical classes and applications that published data indicate are of considerable environmental and/or health concern.
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