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The pooled HR suggested that high miR-21 was clearly related to worse overall survival (HR = 2.27, 95% CI: 1.81-2.86), with a heterogeneity measure index of I = 76.0%, p = 0.001, showing that miR-21 might be a considerable prognostic factor for poor survival in cancer patients.
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Recently, Ki67 index (cell proliferation marker) has been attracting a considerable attention as a prognostic factor in breast cancer but the prognostic significance of Ki67 after neoadjuvant chemotherapy (NAC) has rarely been examined.
However, owing to the considerable methodological variability among prognostic factor studies, results could only be combined by accepting rather flexible inclusion criteria (Crijns et al, 2003).
Clinically, the nature of the organism is critical in that many possess specific virulence factors that have considerable prognostic significance.
DSOF may be a useful prognostic factor for severe sepsis.
Tumor spatial heterogeneity is an important prognostic factor.
Furthermore, solitary liver metastasis is a significant prognostic factor [12 14].
Similarly, comorbidity was not a prognostic factor in our study.
Low PbtO2 is in itself an independent prognostic factor.
Prognostic stratification should include serum albumin concentration, which is an independent prognostic factor.
Pulmonary inflammation is a substantive prognostic factor for Ivor Lewis operations.
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