By only using SNPs with the rarer allele observed at least twice, a misidentification of SNPs due to sequencing errors should not have posed considerable problems as the overall sequencing error rate (including both, indels and base substitutions) is only 1.07% for 454 GS FLX [ 39].
Thus, AD presents a considerable problem in patient management as well.
According to the national State of Homelessness in America 2014 report, while there are considerable problems, such as a shortage of affordable housing, homelessness overall, as well as chronic street homelessness, has been falling for the past few years.
It is a considerable problem in tuberculosis (TB), as it increases the infectious pool in the community (increases the time a patient stays infected) and also the mortality rate (1).
Since 1915, food waste has been identified as a considerable problem and has been the subject of ongoing media attention, intensifying with the launch of the "Love Food, Hate Waste" campaign in 2007.
Regarding compliance with treatment regimens, professionals and some parents highlighted this as a considerable problem whilst patients appeared to be ambivalent about it.
The RNs experienced constipation as a considerable problem among nursing home residents which they felt was due to long-term use of laxatives, dehydration, pain-killers, inactivity, suppression of the need to defecate, or inability to sit during defecation.
His health has been a problem, a considerable problem".
Outcome reporting bias is a considerable problem.
Finally, incomplete documentation of prescriptions was a considerable problem.
