Sentence examples for considerable phenotypic changes from inspiring English sources

We conclude that, despite the considerable phenotypic changes in the Dicer-null NS cells, acute reintroduction of Dicer corrected the major features of the phenotype, most notably their ability to differentiate.

Given the functions of miRNAs in post-transcriptional gene silencing, loss of Dicer and all microRNAs would be expected to result in considerable alterations in mRNA levels and associated phenotypic changes.

After four molting episodes, the honeybee larva reaches the fifth larval instar without phenotypic changes, except for a considerable increase in size.

Phenotypic plasticity has received considerable attention in evolutionary ecology, whereas focus has been laid on long term adaptive phenotypic changes [ 10, 38].

While there is some predictability in this progression at least for certain cancer types, considerable research will still be necessary to delineate combinations of genetic and epigenetic alterations and phenotypic changes associated with malignancy and metastasis.

Now consider all possible phenotypic changes of a certain step size, beginning from the phenotype P.

No phenotypic changes were observed in either of the genotypes.

Hepatocellular carcinomas (HCCs) are characterised by considerable phenotypic and molecular heterogeneity.

However, even patients with mutations in the same gene show considerable phenotypic variability.

Further, DLM induced phenotypic changes were mitigated by the piperine.

If evolution cannot proceed by genetic changes with very small phenotypic effects, then how are the many potentially deleterious effects of large phenotypic changes avoided?