Sentence examples for considerable off target from inspiring English sources
Due to these essential roles of SUMOylation in various cellular processes including CFTR processing, direct inhibition of the pathway may be associated with considerable off target effects.
ChIP-Seq not only revealed enriched binding of ZFPs to their intended sequence, but also considerable off-target binding, especially at promoter regions.
On the genomic scale, these nucleases still show considerable off-target activity though, posing a serious obstacle to the development of therapies.
While interesting, it must be kept in mind that antagomiRs have considerable off-target effects and may also neutralize related, relevant microRNA with conserved "seed" sequences, although the antagomiR approach offers an easily applied and stable means of antagonizing microRNA function in a relatively specific fashion.
Again, agonists were found to have considerable off-target effects in the animal studies.
This made off target effects unlikely.
Considerable genome wide off-target deamination activity outside the Ig loci was reported for AID [36] and brought in context to germinal center-derived lymphoma development [37].
To check if target site conservation is a considerable factor in predicting siRNA off-targets, we searched for sites conserved among human, chimp, mouse, rat and dog.
