This remains a fiercely Democratic state, and Ms. Lingle, as she acknowledged in an interview, will have to overcome the considerable obstacle of having Mr. Obama, who was born in Honolulu, at the top of the ticket.
That's because technology makes it exponentially easier to publicise information than it once was, when everyone from admirable whistle-blowers to far-left anti-liberal subversives like Mr Assange, faced the considerable obstacle of stealing large numbers of physical documents from organisations to back up their claims.
Gaps in this chain that still existed in the 1970s, such as the relationship between air lead and blood lead, presented considerable obstacles to the promulgation of the health-based regulation limiting lead content of gasoline (Bridbord and Hanson 2009).
By contrast, Thomas Pogge highlights the ways in which international practices concerning the distribution of resources create considerable obstacles for prosperity in developing countries.
Limited uptake across the blood brain barrier (BBB) and poor penetration of brain tissue are considerable obstacles to improving drug efficacy against infiltrative malignant tumor cells.
Despite strong local political will and commitment, considerable obstacles to environmental integration still exist, including political instability, lack of understanding, knowledge and experience, and insufficient cross-sector coordination.
However, for next generation development of rhamnolipid production processes and next generation biosurfactants there are still considerable obstacles to be surmounted, which are discussed here.
Still, there are considerable obstacles to a protracted nominating battle.
The world's growing ranks of elected authoritarians may be refashioning democracy in their own image, but they still face considerable obstacles to out-and-out despotism.
The chancellor said there were "very considerable obstacles" to nationalising RBS.
