There was considerable variation between the normalization methods.
However, in view of the considerable errors involved in the normalization procedure it remains questionable whether this represents a true functional enhancement of the transporter function.
Although most of these candidates are considered to be "typical" housekeeping genes and are widely used for data normalization, they exhibit considerable variation in expression stability across various sample sets.
There is currently a considerable debate about whether vessel normalization in brain tumours as observed upon treatment with anti-angiogenic agents will enhance or impair the delivery of concomitant chemotherapeutic drugs (Batchelor et al., 2007; Claes et al., 2008).
We applied different normalization methods and found considerable overlap between the results.
He has become more mean, more rigid, an angry senator who seems bent on destroying his own considerable legacy by doubling down against the normalization of gay rights in the country.
Our key observation is that the incorporation signals of neighboring flows, even after normalization and phase correction, carry considerable mutual information and are important in making the correct base-call.
Ever since polls have been taken on the matter, a considerable majority of the US population has favored normalization of relations with Cuba, but that, too, is insignificant.
Treatment with rhTG1 liposomes resulted in considerable improvement of the ichthyosis phenotype and in normalization of the regenerated ARCI skin: in situ monitoring showed a restoration of TG1 activity, and cholesterol clefts vanished ultrastructurally.
It has been shown that real-time RT-PCR results are highly dependent on the reference genes chosen [ 8], which supports putting considerable effort into validating gene(s) chosen for normalization prior to extensive experimentation.
