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They found a wide range of methodologies, settings and outcome measures, and described considerable methodological limitations, but concluded that "the impact of headache in children and adolescents was substantial".
These three positive studies suffer from considerable methodological limitations.
Even though there are considerable methodological limitations in these studies [41].
In addition, as our systematic review reveals, the studies that have been performed often have considerable methodological limitations.
Finally, four papers were excluded because of considerable methodological limitations [ 32- 34] concerning data analysis, sample selection or study design.
However, the study on the effectiveness of cognitive behavioural therapy in diabetes had considerable methodological limitations [ 13].
Similar(51)
However, due to significant methodological limitations and considerable heterogeneity across studies, evidence to support the reliability of these associations is limited.
While there are some methodological limitations, the design has considerable strengths.
A number of methodological limitations require consideration.
However, considerable heterogeneity within the meta-analytic results and methodological limitations of the identified studies were evident, highlighting areas for future investigation.
The small organ size in these animals, together with limitations in blood sampling, poses considerable methodological challenges.
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CEO of Professional Science Editing for Scientists @ prosciediting.com