They found a wide range of methodologies, settings and outcome measures, and described considerable methodological limitations, but concluded that "the impact of headache in children and adolescents was substantial".
Over recent years there have been considerable methodological developments in the field of animal disease surveillance.
The results demonstrate the potential efficacy of ATO in refractory multiple myeloma, but the validity of these findings is reduced by considerable methodological flaws.
There are however considerable methodological issues associated with these types of measure, and these are made more complex when they are applied in mental health and paediatric settings.
The reduced depth of the photic zone in most intertidal and shallow coastal sediments makes the characterization of its properties a considerable methodological challenge.
There has been considerable methodological research on response-adaptive designs for clinical trials but they have seldom been used in practice.
Accompanying the first-order discussion of these expressions (which is often motivated by philosophical as well as semantic concerns) has been considerable methodological discussion about just where to draw the line between semantic and pragmatic sources of context sensitivity.
Comparisons of prediction accuracies between this approach and other methods such as scaling up from individual tree biomass estimates and biomass expansion factors highlighted considerable methodological differences in the estimates of aboveground biomass and associated uncertainties over a range of stand age and conditions.
These three positive studies suffer from considerable methodological limitations.
This was a carefully conducted study with considerable methodological strengths.
Even though there are considerable methodological limitations in these studies [41].
