The existence of multiple linkage peaks, none or few of which are statistically significant, suggests considerable locus heterogeneity or the existence of multiple mutated genes as recently proposed in an association study using nonsynonymous SNPs in candidate genes (Caporaso, 2006, Rudd et al., 2006).
The patient, who was comorbid for schizophrenia, was found to have a notably reduced cerebellum mass and was characterized by considerable locus-specific changes in DNA methylation and gene expression, with many of these differences being autosomal and tissue-specific.
However, this overall evolutionary history was not reflected in all loci examined, with considerable locus-wise heterogeneity seen in gene tree topologies, levels of polymorphism, genetic differentiation and rates of introgression.
However, considerable inter-loci and inter-individual variability were seen, specifically at some and not all loci (Fig. 1B and Supplementary Material, Table S1).
The genealogical sorting index showed considerable variation across loci and hypothesized lineages.
The evidence of prevalence of this mutation is patchy with few studies looking at this locus and those that have show considerable differences in prevalence between countries.
Congenital cataracts show considerable clinical and locus heterogeneity and represent one of the major causes of vision loss world-wide [ 1].
The Mtb manB gene holds 69% protein identity to the plcpsec110 pan locus and more than 90% alignment extension, making plcpsec110 a considerable putative drug target.
Inspection of graphical genotypes for the locus order generated by the program revealed considerable numbers of misplaced loci and inversions of blocks of loci, which introduced artificial crossovers and inflated maps.
14 Although psoriasis and PsA have been recently shown to have similar susceptibility loci and considerable genetic overlap, 15 it is still not clear that both conditions respond equally well to ustekinumab.
