Sentence examples for considerable limits from inspiring English sources

There are considerable limits on how far government can or should endeavour to direct such measures.

But concern that Obama may have opted for the short-term option at the expense of a longer-term solution has been compounded by the morning-after realisation among immigration rights activists that Obama's sweeping, historic announcement has considerable limits.

It supports the theoretical argument from the first section, which holds that POS theory is confronted with considerable limits and might not be able to explain variance in migrant mobilization across time.

However, notwithstanding the considerable limits represented by the study designs, which were mainly retrospective, the observational studies reviewed seem to support the implementation of isolation (or segregation) measures to reduce the risk of transmission of BCC and PA in CF patients.

Much effort has gone into establishing a suitable animal model for EBV but even the most advanced models, i.e. humanized mice show considerable limits [4].

(VI, B) The use of the main oral hypoglycemic drugs (secretagogues, biguanides, thiazolidinediones) has considerable limits in the hospital framework.

However, bone marrow suppression is considerable, limiting its use in combination with other chemotherapeutic agents.

A considerable limit of all these studies is the lack of information on the dimensions of local recurrence.

Second, the financial resources required to develop the populations needed to map QTL were considerable, limiting the adoption of this technology (see Dekkers 2004, Bernardo 2008, Collard and Mackill 2008, and Hospital 2009 for insightful discussions of lessons learned from QTL studies in animal and plant breeding).

Although the accuracy of prospective event-level measurement in assessing HIV acquisition and transmission risk is well established [ 43, 44], the intensity of follow-up and staff time required was considerable, limiting achievable sample size and the duration of follow-up.

And likely for the same motives: a realistic and grown-up acceptance of their own not very considerable thespian limits, and a taste for high-impact expressive minimalism in performance, the currency of pure movie stars, not of actors per se.