Sentence examples for considerable limitations including from inspiring English sources

Autologous bone provides the optimal source, but the harvest has considerable limitations, including donor-site morbidity, inappropriate form, and lack of sufficient quantities in procedures requiring large amounts of graft [ 1, 12].

We recognize that this secondary analysis has considerable limitations, including a small sample size, the fact that the study was not designed to specifically test the efficacy of PCC among MOC, and that the study population may not be representative of men testing in other venues.

The studies had considerable methodological limitations, including lack of an adequate description of inclusion criteria, population (especially stage of disease) and reference standard used.

However, with such a systemic chemotherapeutic approach, considerable limitations exist including toxicities to healthy tissues and low achievable drug concentrations at tumor sites.

But GPS systems have limitations, including limited battery lives.

Study limitations include self report of race.

Major limitations include the following.

Limitations include its retrospective nature.

Other limitations include the following.

Mobility limitations included limitations on walking and climbing stairs.

Previous research using fish oil as an intervention for cachexia has used the model of pancreatic cancer, however there have been considerable limitations in this research including heterogeneous samples representing mixed tumour types and severity, the use of variable and largely insufficient doses of EPA, and in some cases, the administration of fish oil for short durations [ 57].