However, there are considerable limitations for these two techniques.
Although a few studies have examined the course of depression once symptoms were present (recurrence/persistence, remission), most had considerable limitations: for example, a small sample size (n < 175) [ 13– 15], recruitment from specialist settings [ 15] or only two assessments of depression [ 15, 16].
For PM2.5 components that are measured routinely, a considerable limitation for many studies has been insufficient temporal resolution of PM component data.
Depending on what seems natural in the given context, it is even possible to develop one's own weighting scale [ 11, 14] which is a considerable limitation for comparison of results, unless the weighting values are described and explained.
In Africa, it is mainly used for treatment of acute anemia in SCA[29] [30], since there are considerable limitations of blood transfusion in Africa such as inadequate blood supply, risk of transmission of infections and alloimmunization.
However, over time some considerable limitations of the scale have become apparent.
While computational methods for reduction in false positives due to systematic effects have previously been proposed [ 17], inadequate call coverage is also a considerable limitation of the resequencing array-based approach [ 13, 15].
Although the various biomarkers of bone health can be used effectively for diagnosis and therapeutic monitoring, there are considerable limitations to their predictive value for the individual, and interpretation of small changes during preregistration trials remains uncertain (87, 88).
TDI, for example, bears considerable limitations such as angle dependency, the requirement of high frame rates, and the fact that it is prone to artifacts [ 38, 39].
However, there are still considerable limitations in the availability of clinically graded drugs for triggering innate immune receptors.
