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The computational cost of 3-D similarity methodology on a wide scale, such as PubChem contents, is a considerable issue to overcome.
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With a price tag of $1,000 per month, Saxenda's cost will be a considerable issue, especially as obese patients may need to take liraglutide "indefinitely, like statins," to maintain their weight loss, wrote Siraj and Williams.
However, if they do not record pathways in a standardized way, integration of the results of these efforts will continue to be a considerable issue.
For these reasons, anterior open bite is a major cause of masticatory and phonatory function impairment and also causes considerable esthetic issues to the affected patients [7].
It would appear that the provision of joint training where GPs, employers (including occupational health) and employees might learn from each other's experiences and perspectives, whilst attractive in theory, has considerable practical issues to overcome.
In fact, the ABA, representing some 400,000 lawyers across all walks of legal life, sent a letter to Director Elmendorf earlier this month, taking considerable issue with the contents of Elmendorf's October 9 letter and the research upon which he claims to rely.
Ensuring that food and feed are correctly labeled to indicate whether ingredients are derived from GMOs is a considerable issue facing manufacturers, retailers, and enforcement agencies [ 3].
But "access is a considerable issue for us," Mr. Beard said.
Clean and renewable energy has been a considerable issue in the last decade.
Since, the number of cancer survivors increases, prediction of radiotherapy induced second cancer risks becomes a considerable issue.
The author mentions that the difficulties of matching up MRI measurements with that of anatomical measurements is a considerable issue interfering with making a comprehensive connectivity model of the human brain.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com