Sentence examples for considerable importance that from inspiring English sources

It is of considerable importance that insufficiency subchondral fractures, osteonecrosis, and transient osteoporosis be differentiated, because their treatments and prognoses are quite different.

The fact that there is a population of Pakistanis that refuses to acknowledge that an issue such as acid burning is one of considerable importance that mandates exposure is indeed sad and indicative of a deep sense of denial.

It is of considerable importance that siRNA-mediated functional knockdown of FOXA2 resulted in transcriptional activation of HNF6 and of genes targeted by this factor.

It is of considerable importance that NFAT cooperates with other transcription factors involved in insulin transcription such as PDX1, NEUROD1 and HNF4α.

It is of considerable importance that the gene expression of the HNF4α target genes insulin1 (INS1) and insulin2 (INS2) was significantly repressed (Table 5).

It is of considerable importance, that c-Myb regulates Igf2 (Figure 9), which allows tumor cells to develop an independent autocrine loop thereby integrating EGF and IGF-2 signaling networks [27], [28].

The activities shown by the particles against these resistant isolates are of considerable importance, indicating that the particles can be deployed to reduce the growth of drug-resistant isolates that abound in the environment [35, 36, 51, 52, 53, 54, 55, 56, 57].

This is again of considerable importance, given that academic opinion is divided on the use of transition measures versus serial measures when measuring health outcome.

It is of considerable importance to note that this combination of multivariate analysis techniques with our basic methodology to model disease incidence at zonal level can be generalized to any volume of data over any spatial range for achieving a great degree of predictability on malaria incidence over time under different environmental factors.

It is of considerable importance to note that this can be generalized to any volume of data over any spatial range to achieve a great degree of predictability of malaria incidence over time with respect to the factors considered in the respective study.

In contrast to the prospective examples, it was recognized that some decision makers within sponsor organizations do not realize that regulators also place considerable importance on the additional learning that can be gained from late-stage drug development, which can be enhanced through the application of M&S.