Nevertheless, the law creating the fund includes provisions that establish considerable guidelines.
A study of the relationships between authors of clinical practice guidelines and the pharmaceutical industry found considerable interaction between guideline authors and the pharmaceutical industry [ 47]; another study found that clinical practice guidelines published in journals almost never published conflict of interest statements along with the guidelines [ 48].
Divided into 2 groups (10 individuals with considerable experience in guideline implementation in one group, 11 individuals experienced in guideline development and dissemination in the other), participants were asked to rank the relative implementability of the guideline recommendations.
However, considerable variation in guideline adherence exists among therapists [ 5, 6].
There is considerable variation in guidelines as to the threshold to define clinical significant proteinuria.
There seems to be a 'guideline industry' emerging in many Western countries with a considerable variation in guidelines from different sources (Grol et al, 1998a).
The introduction of a new drug for treatment of a particular disease, or the results from new scientific studies may have considerable influence on guidelines.
Despite the widespread availability of clinical guidelines, considerable gaps remain between the care that is recommended (appropriate care) and the care provided.
Other studies, however, showed considerable advantages of guideline-based intervention focusing on structured medication treatment and adherence compared to a group with treatment as usual in self-reported and physician-assessed depression scores after 12 months [ 41].
These data suggest that management has improved over the last decade, and undoubtedly, the publication of international clinical practice guidelines for management contributed to this trend, although a recent study by Leone et al. showed that there is still room for considerable improvement before guidelines are fully implemented [ 43].
Clinical practice guidelines have considerable potential to improve quality of health care as guidelines become integrated with information systems and electronic medical records [ 12].
