Considerable Grade 3/4 toxicity was encountered (36% for diarrhea, 21% for vomiting and 17% for fatigue).
All three regimens described here are associated with considerable grade III/IV toxicity, in particular, myelosuppression.
Side effects of the chemotherapy regimen were considerable, with grade III or grade IV toxicity occurring in 30% of patients.
Grading the evidence when resources are limited may depend, to a considerable degree, on the subjective decisions of a small number of people.
In our previous study of in situ duct carcinoma [ 12], we identified considerable heterogeneity of grading with about 50% of the patients exhibiting more than one grade (different grades in the same duct, different grades in different ducts in the same area, or different grades in different areas).
Considerable variation in grading systems used to rate the strength of guideline recommendations and the quality of the supporting evidence in Nephrology highlights the need for a uniform, internationally accepted, rigorous system.
The railroad rejected the proposed rerouting of their main rail lines citing that it would result in worse grades than what currently exists and in order to reduce those grades, considerable lengthening of the rail line would be required.
As shown in Figure 7B_4, grade 1 patients had considerable better outcome than grade 2 and 3 patients, while the outcomes for grade 2 and 3 patients were hardly discernible.
College Prep Surveys show that college admissions offices attach considerable importance to grades in college prep courses.
However, the chemotherapy group experienced considerable toxicity – 41% grades 3 and 4.
