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It is noteworthy that even without exposure to any exogenous DNA damaging agents there is considerable gene expression change.
A 2-way ANOVA model incorporating the donor ID (representing the three different genetic backgrounds of the transformed cells) as the additional factor revealed considerable gene expression changes between wtBAC and 3BKO LCLs (Table S5).
In summary, Figure 2C-E suggests four distinct clinical parameters that define groups of patients with considerable gene expression differences.
We found considerable gene expression differences among tissues for those genes of our data set, which carry introns in D. melanogaster.
During the muscle transition between late foetal gestation and lamb at 4 months of age, there are considerable gene expression and physiological changes (Byrne et al. 2010).
CYP1A and CYP2C were the CYPs with the highest gene expression in the intestine and also showed considerable gene expression in the liver.
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Both these CYPs also showed considerable hepatic gene expression levels.
Our initial analysis revealed considerable variation in gene expression among the strains with 1,752 probe sets differentially expressed among strains, 259 with a 2-fold or greater difference in pairwise comparisons of mean expression levels [see Additional file 1.
In a similar manner, Xie et al. [91] found that the action of ZnO-NPs on C. jejuni has stimulated morphology disorder, intracellular components outflow, and considerable release in gene expression of oxidative stress of C. jejuni.
There were considerable variations in gene expression profile changes under such individual stress conditions [30].
Interestingly we found considerable overlap in gene expression between our Braak stage 6 AD cases and controls.
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