Sentence examples for considerable experimental effort from inspiring English sources

Despite considerable experimental effort, acute or chronic ethanol feeding alone failed to cause acute or chronic pancreatitis in animals.

Depending on the biological system studied, several TF KOs represent a considerable experimental effort in order to achieve independent and specific perturbations of the biological system.

However, despite considerable experimental effort, the zinc chaperone protein in E. coli has yet to be identified [ 2, 6, 24- 27].

Even if a comprehensive genome-scale stoichiometric model is already at disposal, a considerable experimental effort is necessary to overlay high-throughput metabolomic and isotopomer flux data for better constraining fluxome estimations [ 42].

The search for new vaccine targets against prokaryotic microorganisms has been aided by extensive use of software motif recognition in sequences; nevertheless, considerable experimental effort is necessary to filter out the most promising candidates.

A cubic ZrO phase has been reported at this interface,[ 8, 9] but this identification has been challenged,[ 10, 11] and despite considerable experimental effort, the structure of the ZrO sub-oxide is still unknown.

The considerable experimental efforts to unambiguously assign intermediate species and to provide reliable quantitative concentrations are thought to be valuable for improving the mechanisms for higher alcohol combustion.

The fluid dynamics aspects of the outflow process are investigated by means of a 3D numerical simulation with the Ansys Fluent CFD solver, while considerable experimental efforts are provided in order to validate the numerical model and finally evaluate the system performances on real case studies.

Due to the biological and pharmaceutical importance of membrane proteins, considerable experimental efforts have been made to better understand their structure and function in membrane environments.

Indeed, generating such models would require considerable experimental and computational effort, and as such it remains as one of the main challenges in systems biology today, if not the main challenge.

Despite considerable experimental and theoretical effort, no compelling scenarios currently exist for the origin of replication and translation, the key processes that together comprise the core of biological systems and the apparent pre-requisite of biological evolution.