One recent example is the considerable heterogeneity amongst naïve donors in NK cell IFN-γ secretion in response to malaria-infected erythrocytes 35.
Another example is the considerable variation in mitochondrial diameter, which again is difficult to explain by the current model but can be interpreted as a kinesin-driven membrane deformation process.
Care provision for HZ and PHN patients, in terms of visits to primary care (general practitioner centres) and outpatient secondary/tertiary care centres (specialist pain clinics and ophthalmologists), inpatient visits (hospitalisations) and prescription costs, for example, is at considerable cost to healthcare systems [ 12- 17].
Before 1966 Robert Moses, for example, was a considerable force in the city; after 1973 he was dethroned, along with many other urban power brokers.
(Surviving artifacts clearly demonstrate that ancient man was already possessed of considerable aesthetic ability; flint, for example, was carefully flaked into attractive, well-balanced forms, and stone carving and pottery were capably handled).
But the range of features represented even in the relatively few pre-1890 examples is considerable.
While evidence showing that sewage is an important disease reservoir is limited to one type of disease and its associated causal agent, the potential for discovery of more examples is considerable, given the sheer numbers of microbes and viruses present in the average human gut and consequently in the average sewage effluent (e.g., see Refs. 91– 91).
Several key features of the system together with the system description and the considerable example of the applications are described.
A considerable number of numerical examples are given for the free vibrations of cross-ply and angle-ply laminated cylindrical, conical and spherical shells with various geometric and material parameters.
For example, considerable effort is required to define the optimal production cell line and growth conditions for high yields, and downstream purification and formulation processes may also be complex and require precise standardisation.
