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The diagnosis of Parkinson's disease (PD) is currently based on the clinical evaluation of extrapyramidal signs with a considerable error rate.
The diagnosis of PD and disease progression monitoring are currently mainly based on the evaluation of clinical symptoms, which is subjective and thus often associated with a considerable error rate.
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Some limitations to the analysis described in this report are, first, the PIN used was incomplete and therefore subject to considerable error rates; second, the large number of predicted miRNA targets makes experimental validation rather difficult.
From the observation that RF also showed a considerable classification error rate (71,31%) it could be presumed that the given clinical subphenotypes are inadequate or not sufficient to serve as sole class predictors.
We recently examined the quality of data contained in the NICE registry and found a considerable lower error rate (6%) [ 16].
As is to be expected, applying the naive unadjusted critical boundary may result in a further considerable type 1 error rate inflation as compared to.
Based on the iterative decoding process and the optimum parameter selection operations, a considerable improvement in the error rate performance is obtained.
The revolution in ultra high throughput sequencing (UHTS) technology may bridge this gap, but the utility of the current platforms is limited by the relatively high error rate and considerable start up and operating cost [12].
The choice of SNPs for colocalisation testing will be shown in this paper to have a considerable influence on the type 1 error rate of colocalisation tests.
Recovering the bulk of these 'ultra-rare' viral mutations, however, requires considerable extra effort – either through reduced error rate or increased coverage.
By only using SNPs with the rarer allele observed at least twice, a misidentification of SNPs due to sequencing errors should not have posed considerable problems as the overall sequencing error rate (including both, indels and base substitutions) is only 1.07% for 454 GS FLX [ 39].
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