However, use of these drugs is associated with considerable side effects such as bone marrow toxicity (GCV) and nephrotoxicity (foscarnet and cidofovir) [13], [14].
However, these medications can be accompanied by considerable adverse effects, such as cognitive impairment and dependency [ 3- 5].
Antipsychotics have only limited efficacy for treatment of neuropsychiatric symptoms in patients with dementia but are associated with considerable side effects such as accelerated cognitive decline, 8 risk of stroke and death.
Moreover, fluoroquinolones, being the preferred oral empirical treatment for AP, are associated with considerable side effects such as dysglycemia and Clostridium difficile infections, especially in the elderly and subjects with co-morbidity [ 17, 18].
The traditional noninsulin antihyperglycemic agents (sulfonylureas, thiazolidinediones, alpha-glucosidase inhibitors) show similar efficacy in reducing HbA1c (0.7%–1.0%), but are all associated with considerable side effects, such as hypoglycemia and weight gain, among others.
It is known that the efficacy of psychotropic drugs is limited and that their use is associated with considerable side effects such as extrapyramidal symptoms, somnolence, and increased risk for stroke, pneumonia, and mortality [ 4- 7].
The latter is due to the increased productivity of farms, engaging in global market competition [18] meanwhile causing considerable adverse environmental effects, such as soil acidification [19].
Curcumin as a natural flavonoid from Curcuma longa has considerable effects on nervous system such as, antidepressant, antinociceptive and neuroprotective effects.
Although olanzapine showed considerable efficacy, its adverse effects, such as weight gain and sedation, limits its use for tic control [ 4, 10].
With such considerable effects on associated morbidity and mortality, the economic burden associated with sepsis has recently been estimated at 17 billion dollars each year in the USA alone [ 1].
