Sentence examples for considerable downregulation of from inspiring English sources

Tissue specific RNAi using various Gal4 driver lines resulted in a considerable downregulation of CycG activity as visualized by reduction of CycG mRNA and CycG protein levels (figure 3), respectively.

Analysis of the expression differences between purified and non-purified CMs revealed considerable downregulation of early mesodermal and homeobox genes, and upregulation of cardiovascular and structural genes such as actins and extracellular collagens.

Also in strains lacking BLR1 or BLR2 considerable downregulation of transcript levels occurred [ 15].

Figure 1(b) shows the scanned ratios between ENT3 and TBP mRNA expression and confirms the very considerable downregulation of the ENT3 gene by the siRNA treatment.

Regardless of the absence or presence of 3-hydroxybutyrate, we noticed a considerable downregulation of BDH, OXCT1 and ACAT1 mRNA levels in all cell lines in hypoxia.

Finally, we also detected a considerable downregulation in the levels of M6PRBP1.

Similarly to the transcripts that were upregulated following LPS administration, RU486 prevented the dowregulation of 25 out of 42 genes, implying that endogenous GCs are required for both upregulation and downregulation of a considerable number of genes.

The substantial ESR-mediated downregulation of general translation by celecoxib might have considerable implications for the interpretation of some of the other reported COX-2-independent effects of this drug.

Moreover, the downregulation of ZO-1 has been associated with a considerable increase of the intestinal permeability [ 48].

Though we did not observe any significant downregulation of hTERT mRNA in microarray analysis, real-time PCR results showed considerable hTERT mRNA downregulation in Gleevec-treated K562 cells (Additional file 1: Figure S9, Table S2).

Downregulation of eIF4E2 relieved miRNA repression of reporter expression.