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The genes encoding the CTX-M-1 and CTX-M-2 groups are separated by over 400 mutations, which indicates considerable diversification of the blaCTX-Ms.
For example, in enterohemorrhagic E. coli considerable diversification of prophages carrying virulence determinants has been observed, likely indicating independent infections of host bacteria by different bacteriophages carrying these virulence determinants [ 55].
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We find that autogenic photophores were likely present in some form in the ancestor of pelagic squid, and have undergone considerable diversification in terms of anatomical positioning, morphological complexity, and emission properties.
While some L. monocytogenes strains show evidence for considerable diversification by homologous recombination, our understanding of the contribution of recombination to L. monocytogenes evolution is still limited.
As in Drosophila, murine Mst1/Mst2, in a redundant manner, negatively regulate the Yorkie ortholog YAP in multiple organs, although considerable diversification in the pathway composition and regulation is observed in some of them.
The differences between SShD of different species were therefore of a similar magnitude as the SShD in each species, indicating a considerable diversification.
Our comparative genomic analysis of the GH18 protein family indicates that considerable loss, duplication and diversification of these genes occurred in vertebrates.
These trees give considerable insight into the early diversification of Diptera.
Thus, our study indicates the presence of a considerable positive selection pressure in diversification of the Prochlorococcus core genome, which in turn, suggests an appreciable role of random genetic drift in vertical niche partitioning of the strains.
In general, the use of complete mitochondrial genomes for resolving questions of the early diversification of Diptera shows considerable promise.
Overall, the considerable gene acquisition/loss promoted the genetic diversification of V. parahaemolyticus strains to form distinct clonal or semi-clonal complexes.
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