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Each family shows considerable diversification and evolution, with the hyracodonts evolving into the gigantic indricothere Paraceratherium (formerly called Baluchitherium or Indricotherium), the largest land mammal that ever lived.
The differences between SShD of different species were therefore of a similar magnitude as the SShD in each species, indicating a considerable diversification.
The genes encoding the CTX-M-1 and CTX-M-2 groups are separated by over 400 mutations, which indicates considerable diversification of the blaCTX-Ms.
While some L. monocytogenes strains show evidence for considerable diversification by homologous recombination, our understanding of the contribution of recombination to L. monocytogenes evolution is still limited.
For example, in enterohemorrhagic E. coli considerable diversification of prophages carrying virulence determinants has been observed, likely indicating independent infections of host bacteria by different bacteriophages carrying these virulence determinants [ 55].
We find that autogenic photophores were likely present in some form in the ancestor of pelagic squid, and have undergone considerable diversification in terms of anatomical positioning, morphological complexity, and emission properties.
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Our data suggest that P. comma and P. g-argenteum have diverged in the past 2 3 mya, during which time there has been considerable morphological diversification between them.
Since regions outside of the motor head domain direct many interactions, considerable functional diversification might be achieved through the evolution of the protein domain combinations.
Together with the high molecular diversity of the KTRAP gene family observed in our study, considerable intraspecific diversification has been reported earlier with copy number variations [ 86– 91] in ethnic human populations and allelic variations in sheep.
Prior to this, was a period of considerable angiosperm diversification which occurred during the lower Cretaceous, a relatively warm interval in Earth history with elevated levels of atmospheric carbon dioxide [ 60].
There has been considerable evolutionary diversification to the primary specificities of the CMGC kinases such that paralogs diverged by more than two billion years have almost no overlap in their preferences.
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