Another potential weakness relates to the considerable number of discontinuations recorded over the course of the study.
The intent-to-treat (ITT) population was the a priori analysis population, but due to the considerable number of discontinuations, the per-protocol (PP) population was used for the primary efficacy and OSDI analyses, and the ITT population was used for sensitivity analyses.
These adverse drug effects often result in premature drug discontinuation, as well as considerable morbidity.
There was considerable variation between individual trials regarding discontinuations due to lack of efficacy at 12 weeks, for celecoxib and naproxen.
Until 1962 it was linked to Saint-Denis by rail, as well as by paved road; discontinuation of the railway was followed by considerable improvement of the road.
In contrast, however, discontinuation of clopidogrel therapy perioperatively may result in considerable therapeutic and surgery-related disadvantages.
Vaccination of individuals prior to the discontinuation of routine vaccination may provide some, possibly considerable, protection against infection [ 11, 23, 24], although it may also result in more mild cases which may be harder to detect.
Counselling with regard to the timing of drug discontinuation and instruction for requantification of proteinuria, represented a considerable component of the pre-pregnancy counselling process.
However, more recently it was shown that both SDD and SOD markedly affect the bacterial ecology, with rising ceftazidime resistance prevalence rates in the respiratory tract during intervention and a considerable rebound effect of ceftazidime resistance in the intestinal tract after discontinuation of SDD [ 57].
They found that SOD and SDD had marked effects on the bacterial ecology in an ICU, with rising ceftazidime resistance prevalence rates in the respiratory tract during the intervention and a considerable rebound effect of ceftazidime resistance in the intestinal tract after discontinuation of SDD.
