Sentence examples for considerable difficulty that from inspiring English sources
The word "concretely" was removed, and the sentence simply reflects the considerable difficulty that was reported in the Lüscher and Palmiter papers to avoid compensatory effects for Grin1 deletion.
A nice example of the challenge with ion channel manipulations with genetic methods was the considerable difficulty that was reported by the Palmiter and Lüscher groups in 2008 for DA neuron Grin1 ablation.
It's not quite Mr. Romney's constant description of a tattered and threadbare country, but it does acknowledge the considerable difficulties that remain.
Concorde had other considerable difficulties that led to its dismal sales performance.
It also underscores the considerable difficulties that both the military and the detainees appear to have had in wrestling with the often thin or conflicting evidence involved.
He felt that the Annings should not live in such "considerable difficulty" considering that they have "found almost all the fine things, which have been submitted to scientific investigation..."..
VON RIBBENTROP: On 17 November 1938 Lipski came to see me and declared that the problem involved considerable difficulties and that the Danzig question in particular was very difficult in view of Poland's entire attitude.
She also said that she had "considerable difficulty" accepting the argument that business people Brandis met with would all need to be consulted, and said it was unlikely they would be unreasonably affected enough to require consultation as part of the FoI process.
We chose to control for age and gender during analysis rather than matching for these variables during enrolment, because of considerable logistic difficulties that we would have encountered in identifying appropriate matched controls.
The chairman told those present that "considerable difficulty had been encountered in making plans which would not only be ethically acceptable and feasible but which, at the same time, could produce information of value".
As a result, a designer often encounters considerable difficulty in achieving a structural solution that meets the target displacement and attains a desired yield mechanism.
