Although novel therapeutic approaches such as anti-GD2 immunotherapy have improved patient survival rates (2-year event-free survival (EFS) of 66% reported in high-risk neuroblastoma), 5-year survival rates are currently not available and this therapy has considerable deleterious side effects (Yu et al, 2010).
As presented above, there is considerable data associating hypocapnia with deleterious effects on brain physiology and worse clinical outcomes.
However, in recent years, application of established cryobiological principles to the preservation of multicellular tissues and organs has demanded considerable attention to ways of circumventing the deleterious effects of ice and thermal stresses in bulky tissues.
At the same time, the need to protect normal tissue from the deleterious effects of radiotherapy has driven considerable research into the design of effective radioprotectors.
Actually, evolution can only produce a genome devoid of "junk" if and only if the effective population size is huge and the deleterious effects of increasing genome size are considerable (Lynch 2007).
TE proliferation and genome expansion may have had deleterious effects on powdery mildews, entailing a considerable loss of genes that has resulted in these pathogens being entirely dependent on living host cells [ 7].
Rural poor households are subjected to considerable and protracted financial hardship due to the indirect and longer-term deleterious effects of how they cope with out-of-pocket healthcare costs.
I've gone to bed angry loads of times, with no particular deleterious effects.
Several studies also contradict the conclusion that these chemicals have deleterious effects.
