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As occurs with many other RNA viruses, HCV exhibits a considerable degree of sequence variation over the whole genome.
Interestingly, GLS2 shares a considerable degree of sequence similarity with GLS1.
This role of highly connected proteins is further indicated by a considerable degree of sequence conservation [ 21- 25].
It has been noted that all FAR protein sequences exhibit a consensus casein kinase II-type sequence that occurs in approximately the same place, despite the considerable degree of sequence diversity among FARs [ 19, 24, 67, 68].
This was unexpected because the proteins are similar in terms of overall size, shape, and number of amino acids, with a considerable degree of sequence conservation (≍30 to <80%%).
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Within an α-α-superhelix the structural constraints are on the entire array rather than the individual repeat; a considerable degree of variability with respect to both sequence and structure can therefore be accommodated [2].
Analysis of gene and genomic variation has been revolutionised by the advent of next-generation sequencing technology, revealing a considerable degree of genomic polymorphism.
Despite this apparent simplicity and relatedness at the sequence level, coiled coils display a considerable degree of structural diversity: the helices may be arranged parallel or anti-parallel and may form a variety of oligomer states.
Despite this apparent simplicity and relatedness at the sequence level, coiled-coils display a considerable degree of structural diversity; the helices may be arranged parallel or antiparallel and may form a variety of oligomeric states.
Transposase sequences found in chromosomes show a considerable degree of diversity and degeneracy.
Further comparisons (as shown in Figure 4) of top ranked genes between our sequenced data with microarray data showed that there is a considerable degree of overlap between the two especially in the intracellular samples.
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