These issues must be addressed as they can add significantly to the workload in processing the data and pose considerable challenges for data analysis.
Similarly, sequencing RNA from complex microbial communities, or metatranscriptome sequencing, also poses considerable challenges for data analysis because the genomes for most of the organisms are not known.
It might introduce some considerable bias to the data analysis when a patient is selected for transplantation and follow-up time is censored at the time of transplantation.
The studies described by Gregersen and colleagues [ 1] certainly exemplify a collaborative approach backed up by considerable technology and advanced data analysis.
One of the researchers with considerable experience in qualitative data analysis (EH) read all the transcripts as the interviews were being conducted and identified initial meaning units using open coding.
Mass data from such experiments, e.g., DNA microarray, yeast two-hybrid or ChIP-chip assay, possess considerable challenges for their statistical data analysis.
Considerable intellectual support, computational and data analysis tools were provided by Adam Arkin, Katherine Huang, Morgan Price, Eric Alm, Dan Kirshner, and Kimmen Sjölander – sufficient gratitude cannot be expressed for their generous help.
Although integration of different kinds of data has the potential to add considerable power and robustness to data analysis (7), asking questions across domains of biological knowledge also requires significant effort and expertise (8).
Furthermore, if the SPSS default of listwise deletion of missings is used, all cases that have any missing values across all 24 items are lost to analysis, so considerable data could be lost.
The discrete Finite Element Method (FEM), for example, can be employed for this purpose, though FEM analysis may involve considerable data preparation effort and computing time.
