Obviously, all prediction models exhibit a considerable constraint regarding their ability of finding potential target sites.
This heuristic cutoff of 15% conservation is three times the genome-wide average and four times the average within popUncons elements (supplementary fig. S4 A, Supplementary Material online), implying that these regions were subject to considerable selective constraint for the majority of vertebrate evolution.
But even armed with such a mandate, analysts say, Mr. Hollande would probably face considerable constraints in pressing for some of the solutions he has championed, including the creation of so-called euro bonds jointly guaranteed by all 17 nations that currently use the single currency.
The latter approach, however, poses considerable constraints in terms of imaging depth and laser cytotoxicity and thus is unsuitable for tracking immune cells around islets over longer time spans.
In nontheme news, while the grid design around the theme imposes considerable constraints on fill, there is an interesting range here.
The results for SVR are to be expected, as we treated relevance judgments as linearly increasing absolute scores, which imposes considerable constraints on SVR.
In particular, despite considerable constraints on folding, no regular overall structure of the bacterial chromosome has yet been identified.
The largest discrepancies across inversions are seen for the regions of South and East Asia and for tropical and South America owing to the poor observational constraint for these areas and to considerable differences in the modelled transport, especially inter-hemispheric exchange rates and tropical convective mixing.
That's not a constraint for Microsoft".
