Sentence examples for considerable conformational changes from inspiring English sources
Uracil binding induces considerable conformational changes in UNG, bringing key residues in optimal distances to favour catalysis (Slupphaug et al., 1996).
The known CB1 ligands are highly diverse structurally, so CB1 receptor may undergo considerable conformational changes to accept different ligands, which is challenging for molecular docking methods.
In the mutant complexes, the NADH pyrophosphate moiety undergoes considerable conformational changes, reducing its interactions with its binding site and probably indicating the initial phase of ligand expulsion from the cavity.
Thus it has been postulated that considerable conformational changes are required to enable laminin binding [ 1].
A new cocrystal structure of Ire1 RNase with an oligonucleotide bound, which we provide in this work, does not support considerable conformational changes in the position of Y1043.
This data revealed considerable conformational changes in the transmembrane domain of P-gp as it switched between the empty, ATP-bound and ADP-vanadate trapped conformations.
To maximize the interaction of the host and the guest, carboxylates of more than five carbon chains could penetrate through the space between the two pyrenyl pendants of the host, triggering a considerable conformational change of the fluorophores.
The interaction of the C-terminal region of FEN-1 with PCNA involves a considerable conformational change that redefines part of the receptor peptide binding site: upon peptide binding, an intermolecular β-sheet interface is created between the two partners (contributing to overall 1.5 Å RMSD for interface Cα atoms between the bound and free receptor conformation).
In comparison, the structure of the isolated polymerase displays considerable conformational fluctuations, indicative of large-scale conformational changes and local loss of secondary structure that affect in particular the N-amino terminal region and the thumb domain.
In the presence of miR-21, DNA walkers are activated to walk continuously along DNA tracks, resulting in conformational changes as well as considerable increases of the signal ratio produced by target-respond and target-independent reporters.
The mechanism of ligand binding coupled to conformational changes in macromolecules has recently attracted considerable interest.
