Taken together, our results demonstrate that the intraneuronal development of AD-like amyloid pathology includes a mixture of molecular species (Aβ, APP and CTFs) of which a considerable component is Aβ; and that the early presence of these species within neurons has deleterious effects in the CNS, even before the development of full-blown AD-like pathology.
Thus, through a process of selection between expatriate specialists and a group of long-term residents, culturally and socially integrated MDs emerged as a structural and considerable component of the medical workforce in Mozambique.
For most diseases and outcomes, a considerable component of the prognostic variance remains unknown, and may remain so for the foreseeable future.
A considerable component of workload in larger teaching hospitals, and especially in those with a significant cancer-care profile, involves reviewing studies performed in outside hospitals, referred in for second opinions or for multi-disciplinary care.
The indirect costs of DN, including missed days of work and decreased productivity, are a considerable component of total costs [ 7].
In advanced PCa, healthcare decision makers can expect a considerable component of care to be provided in the inpatient and outpatient hospital settings.
Counselling with regard to the timing of drug discontinuation and instruction for requantification of proteinuria, represented a considerable component of the pre-pregnancy counselling process.
SRH has been shown to be stable over time in population-based studies, suggesting that a considerable component of SRH reflects an aspect of one's enduring self-concept and, to a lesser extent, a spontaneous assessment of one's health status.
The nutrient mixture contained a considerable component of GSH that was taken up by yeasts during rehydration (Figure 4b) and we also observed an upregulation of genes involved in GSH metabolism following rehydration with nutrients (Figure 3c).
Particularly in low-income dwellings, electrical showerheads represent by far the highest electrical loads, resulting in a considerable component in the monthly energy bill.
