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This suggests that considerable clusters of tissue-specific genes do exist in higher eukaryotes.
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Figure 3 shows considerable clustering of lactate concentrations around 2.2 mM for this group.
The PCA scores plot of the first two principal components (Figure 4A) showed considerable clustering of the three groups, albeit with some overlap between the groups.
The PCA scores plot of PC1 versus PC2 (Figure 5B) showed considerable clustering of the four groups of mice, albeit with some overlap between them.
Another considerable cluster was related to development in general and to brain development in particular.
There was considerable clustering of substance use at the patient level as indicated with an ICC of 0.25.
In contrast, both Satterthwaite and K-R methods tend to be conservative, especially when a considerable cluster size variation exists.
Variance component analyses showed that service areas account for 39.4% of the total variance of GP-consultations and imply considerable clustering of consultation rates within areas (Table 5).
Therefore, this method will preserve the validity of the Wald F test; however, its conservativeness may cause power loss, especially when considerable cluster size variation.
In addition, a record linkage study in Utah (Seger et al. 2011) indicated that there was considerable clustering of EC in families, even accounting for obesity.
Finally, state-level random effects are significant; the residual intraclass correlation is still appreciably large, indicating that even after controlling for individual, household and community factors, there is still considerable clustering of antenatal service utilization at the state level.
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