Sentence examples for considerable clinical impact from inspiring English sources

Thus, detection of mutations associated with Gleevec resistance is of a considerable clinical impact.

Among all of the variants that were detected in both BRCA1 and BRCA2 genes, only the c.5095>T has considerable clinical impact on BRCA1 function [ 76].

Despite OSA's considerable clinical impact, a comparative analysis of the SEP between canine osteosarcoma and normal osteoblast cells has not been described in the veterinary literature.

Association of elevated serum β2MG with both low eGFR and decline in eGFR from baseline might have considerable clinical impact, since these surrogates are directly related to inferior allograft survival [ 3, 7, 11, 12] and, when combined, the negative effect is even more pronounced [ 9].

The anatomical variation of RAH is related to its number, presence, or absence, and the diverse origin from ACA is of considerable clinical impact mainly from the point of view of the surgical procedures involving the anterior portion of the circle of Willis or the topographically related structures.

The present results indicate that addition of serum PON1 activity measurement to the biochemical profile could improve the diagnosis of fatty liver in dairy cows, which would have a considerable clinical impact and lead to greater profitability in the dairy industry.

Although considerable controversy exists about the clinical impact of pneumococcal drug resistance (2 ), the prevalence of single-drug and multidrug resistant pneumococci has increased in the last 2 decades (3, 4 ).

Although the themes and subthemes have been presented separately, the reasons doctors continue to prescribe, or do not cease, PIMs are multifactorial, highly interdependent and impacted by considerable clinical complexity.

The appropriate use of PI3K/AKT/mTOR signaling pathway inhibitors remains to be refined in endocrine resistance; however, clinical trials suggest that their clinical impact will be considerable.

The clinical impact of the SIRRIM technique could be considerable, considering that it might become a viable surrogate to other techniques.

As the issue is of considerable clinical importance, particularly for public health strategies aimed at reducing mortality, we contrasted the population-wide impacts on the all-cause and CVD mortality of diabetes vs. CVD.