Several subjects displayed considerable changes in individual cell populations throughout the investigation; however, samples still clustered on the basis of individual, further supporting the existence of a stable kinotype.
Teague et al [ 67] showed that T-cell activation was associated with considerable changes in expression profile compared to resting T cells and, as expected, many genes associated with cell division were activated.
Although Dicer-null NS cells are grossly similar to their wild-type counterparts, expressing Nestin and Sox2, for example, loss of Dicer and microRNAs results in considerable changes in mRNA transcript levels in NS cells, with sets of both up- and down-regulated transcripts.
Considerable changes in the surface of porcine kidney epithelial cells have been detected during H. parasuis attachment, including an increase in the number of membranous projections [ 12].
Strikingly, depletion of FBXO28 in HCT116 cells resulted in considerable changes in gene expression already after 16 h of siRNA transfection, and the majority of the differentially expressed genes were downregulated (88 and 71% at 16 and 36 h, respectively (GEO Accession no; GSE36112).
RVFV infection decreased the phosphorylation of AKT on its major activation site S473 without considerable changes in the total amount of AKT in comparison with uninfected cells (Table 1 and Fig. 4).
During differentiation IK amplitudes increased, while IA decreased without considerable changes in current-voltage dependencies.
