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This has resulted in considerable change to the social and cultural landscape in the world's advanced economies.
The Qualifications and Curriculum Authority (QCA) admits the national picture is "variable" and that adoption of the diplomas means "a considerable change to the routine and practice of schools in the way that they teach children".
The news comes just days after Graham announced a considerable change to how the Y Combinator start fund works, with startups receiving a much smaller initial investment and more face-time and input from advisors in the form of office hours.
They could literally trade places and there wouldn't be a considerable change to either of their women's health agendas.
As a result, any substituent at this position should also result in a considerable change to the IP compared with the parent compound.
If the removal of the outlier resulted in considerable change to the effect sizes of other factors in the model represented by the model parameters or changed the parameter significance levels and hence the overall conclusions, then the outlier was removed from the final model reported.
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He said: "There have been considerable changes to A-level science followed by GCSEs.
The Last Interglacial Maximum caused considerable changes to landscape zones on the Southern Kurils.
This work demonstrates that commonly used antioxidant supplements may cause considerable changes to cellular redox state and the outcome of differentiation.
Moreover, to avoid considerable changes to the nature of regional heatwaves it is absolutely crucial that global warming is minimized within the bounds of the Paris agreement.
This idea, which involved considerable changes to existing procedures, was applied to some programs on a selective basis but never had the impact its designers envisaged.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com