Sentence examples for considerable challenge as from inspiring English sources

Di Canio's successor faces a considerable challenge as he endeavours to repair shattered morale and steer Sunderland clear of relegation waters.

Numerical simulation of solids production presents a considerable challenge as intricacies of breakout processes must be correctly simulated in order to correctly predict rates of solids production.

The provision of many essential multiprotein complexes of higher eukaryotes including humans, can be a considerable challenge, as low abundance and heterogeneity often rule out their extraction from native source material.

The empirical testing of the above ideas faces considerable challenge as a standard correlation or coherence analysis do not offer sufficient information on the relation between the two signals A and B. Recently, advanced connectivity tools have been proposed [25] [28], [32] [40] which aim at parsing the synchrony into directional interaction.

The characterization of pDC lineage has presented a considerable challenge, as pDC display molecular markers and features of several cell types and can be derived from multiple progenitors.

Estimating the disease prevalence and test accuracy (sensitivity and specificity) for two dependent screening tests when the status of individuals who are negative on both tests is unverified represents a considerable challenge, as the disease rates for individuals negative on both tests are not identifiable without additional assumptions.

But three years on from 2008, we still face considerable challenges, as the continuing eurozone crisis demonstrates.

But he will face considerable challenges as he tries to realise his vision of expanding Disney internationally and leading the company into a digital future.

The Democrats face considerable challenges: as of January, the Senate Republicans' $4.9 million war chest dwarfed the $212,000 held by the Senate Democrats, who are currently saddled with a $1.5 million debt from the last election cycle.

The sport still faces considerable challenges as it copes with ever-greater inflows of money and a failure among the highest echelons of the sport show the same willingness to evolve and adapt to modern sensibilities as many of the supporters have.

The pharmaceutical industry is facing considerable challenges as shown by the ever-increasing attrition rates for new drug development projects across all R&D phases.