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Furthermore, autologous bone grafts have shown considerable bone resorption before bone healing [ 3, 4].
There was considerable bone resorption at the osteotomy sites mainly involving the normal host bone rather than the graft itself.
Considerable bone resorption in the proximal femur as an answer to stress shielding of the bone surrounding total hip implants has been demonstrated after total hip arthroplasty with a medullar fixation [ 1- 3].
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Superimposition of sequentially acquired experimental images and simulated structures revealed that in silico simulations deposited thin and homogeneous layers of bone whilst the experiment was characterized by local areas of strong thickening, as well as considerable volumes of bone resorption.
Anti-resorptive agents all inhibit bone resorption.
Overloading of the peri-implant bone has been reported to result in bone resorption [3 5], and the concentration of considerable stress in the load-side peri-implant bone observed in our study confirms this.
CTGF/Integrin αVβ3 pathway is now receiving considerable attention as a therapeutic target in diseases associated with increased bone resorption, such as RA.
Metastatic breast cancer cells stimulate osteoclast-mediated bone resorption, inducing a marked osteolysis that is responsible for considerable morbidity [ 4, 5].
Of considerable interest is the fact that, when various bisphosphonates of various potencies to inhibit bone resorption were investigated, their effect on the mevalonate pathway corresponded well to that of inhibiting bone resorption [ 24].
Kajiya, H. Calcium signaling in osteoclast differentiation and bone resorption.
In the 30's, bone resorption begins to outpace bone formation, causing a gradual loss of bone density.
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